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Cancer

"H2 plays a promising therapeutic role as an independent therapy as well as an adjuvant in combination therapy, resulting in an overall improvement in survivability, quality of life, blood parameters, and tumour reduction." 

Background: Cancer remains a challenging target to cure, with present therapeutic methods unable to exhibit restorative outcomes without causing severe negative effects. Molecular hydrogen (H2) has been reported to be a promising adjunctive therapy for cancer treatment, having the capability to induce anti-proliferative, anti-oxidative, pro-apoptotic and anti-tumoural effects. This review summarises the findings from various articles on the mechanism, treatment outcomes, and overall effectiveness of H2 therapy on cancer management. Methods: Using Cochrane, PubMed, and Google Scholar as the search engines, full-text articles in the scope of the study, written in English and within 10 years of publication were selected. Results: Out of the 677 articles, 27 articles fulfilled the eligibility criteria, where data was compiled into a table, outlining the general characteristics and findings. Throughout the different forms of H2 administration, study design and types of cancers reported, outcomes were found to be consistent. Conclusion: From our analysis, H2 plays a promising therapeutic role as an independent therapy as well as an adjuvant in combination therapy, resulting in an overall improvement in survivability, quality of life, blood parameters, and tumour reduction. Although more comprehensive research is needed, given the promising outcomes, H2 is worth considering for use as a complement to current cancer therapy

Chemotherapy

Brain Cancer

Apoptosis

Apoptosis is the normal, planned death of damaged cells in your body. It's an important process that helps keep you healthy. But when it happens too often or not often enough, you can develop problems like cancer or Alzheimer's disease.

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It's part of its signaling apparatus.

Molecular hydrogen modulates apoptosis, it doesn’t simply turn it on or off. By selectively reducing damaging hydroxyl radicals, Hâ‚‚ prevents excessive apoptosis in healthy cells (mitochondria-driven, caspase-dependent pathways) while allowing or even restoring apoptosis signaling in stressed or cancer cells through redox and inflammatory pathway normalization (e.g., p53, NF-κB, MAPK balance).

 

It's the traffic cops-at-the-intersection analogy. It pushes back the east-west traffic to let the north-south traffic go through with less resistance.

 

It enables and fortifies the processes that promote cell apoptosis where it's supposed to be and prevents it where it shouldn't be. It keeps the clock working properly.

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